Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction

Inclusion Criteria: * DSM-IV-TR diagnosis of Drug addiction disorder; * Age 18-65 years old; * Proficiency in Mandarin language; * Failure to detox more than three times; * Capacity to provide informed consent (understanding of the study purpose and methods); Exclusion Criteria: * Multidrug abuse and formation of addiction; * Serious and unstable organic diseases (e.g. unstable coronal heart disease); * Any history of seizure disorder or hemorrhagic stroke; * Past stereotactic neurosurgical intervention; * Neurological disease (Abnormal PET-CT, MRI, EEG) * Contraindications of MRI-examination, e.g. implanted cardiac pacemaker/ heart defibrillator; * Contraindications of stereotactic intervention, e.g. increased bleeding disposition, cerebrovascular diseases (e.g. arteriovenous malfunction, aneurysms, systemic vascular diseases); * HIV positive; * Pregnancy and/or lactation;