Study to Compare Pharmacokinetics & Pharmacodynamics of Warfarin & Esmolol in the Absence & Presence of MEDI0382

Inclusion Criteria:. * Healthy volunteers aged ≥ 18 to 45 years * BMI between 18 -30 kg/m2 * Females of childbearing potential who are sexually active with a nonsterilized male partner must use at least one highly effective method of contraception Exclusion Criteria: * Any concurrent condition that in the opinion of the investigator would interfere with the evaluation of the investigational product * Receipt of investigational product as part of a clinical study or a GLP-1 analogue containing preparation within the last 30 days or 5 half-lives of the drug (whichever is longer) at the time of screening. * Concurrent participation in another study of any kind * Severe allergy/hypersensitivity to any of the proposed study treatments or excipients. * History or presence of gastrointestinal (GI), hepatic, or renal disease or any other conditions known to interfere with absorption, distribution, metabolism or excretion of drugs. * Impaired renal function is defined as estimated glomerular filtration rate (eGFR) \< 60 mL/minute/1.73 m2 at screening. * Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of screening. * History of hemophilia, von Willebrand's disease, lupus anticoagulant, or other diseases/syndromes that can either alter or increase the propensity for bleeding.