[11C]NOP-1A and Cocaine Use Disorders

\[A\]Cocaine use disorders Inclusion criteria: 1. Males or Females 18-50 2. Fulfill DSM-5 Diagnosis for Cocaine use disorder 3. Medically Healthy Major exclusion criteria: 1. Pregnancy or lactation 2. Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use, and recreational marijuana/alcohol use) 3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain (e.g., morphine, suboxone, SSRIs, etc.) \[B\] Healthy controls Inclusion criteria: 1. Males or Females 18-50 2. Absence of present or past psychiatric conditions (including alcohol or drug use disorders) 3. A negative urine drug screen 4. Medically Healthy Major exclusion criteria 1. Pregnancy or lactation 2. Medical, psychiatric or drug \& alcohol use disorders 3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain 6. Family history of a psychotic disorder, manic episode, drug use disorders in first-degree relatives.