Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes

Harvard School of Public Health (HSPH)22,000 enrolled

Overview

the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).

Study Type

OBSERVATIONAL

Enrollment

22,000

Conditions

Obesity

Interventions

fishOTHER

fish intkae

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 11,323 women of European ancestry. * Informed consent was obtained from all participants. The DNA extraction methods, quality control measures, * SNPs genotyping and imputation data are available . * Both cases and controls with genotyping data are available based on GWASs Exclusion Criteria: * participants without genetic data

Outcomes

Primary Outcomes

weight changes

long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint

Time frame: 6-10 years

Data from ClinicalTrials.gov

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