Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment

Patients eligible for inclusion in this study must fulfil all of the following criteria: * Subjects should be capable of giving their informed consent with sufficient knowledge of the Dutch, French or German language; * Males and females, 18 years and older; * Be assessed as suffering from moderate to severe neuropathic pain across the screening process with pain intensity (numeric rating scale - NRS) ≥ 4/10, * At the time of screening pain symptoms have to be present for at least one (1) month, with a maximum of 24 months; * Sensory disturbances present in the skin area of maximal pain; * At the time of screening pain is clearly related to the presence of a localized neuropathic pain syndrome. * Male or female patients of child producing potential\* must agree to use contraception or take measures to avoid pregnancy during the study and until after the final treatment; * Women can only be included after negative pregnancy test; Exclusion Criteria: * Age \< 18; * Pregnant and breastfeeding women; * Infection in the painful skin region; * Poorly healed or non-healed wound or scar in the painful skin region as well as presence of cutaneous abnormalities (non-intact skin barrier) within the painful skin region related to dermatological conditions; * Known and/or strong suspicion of allergy to the study medication, known skin disorder (resulting in disruption of the normal skin barrier); * Previous treatment with any of the three medications included in the study protocol for the same painful area within the last 12 months at the time of screening; * Risk of heart failure and/or renal failure.