Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section

Mansoura University140 enrolled

Overview

postpartum hemorrhage (PPT) represents one of the major causes of maternal mortality . Tranexamic acid is used in many studies in management of PPH in combination with ecobolics. this study aims to evaluate the possible value of the use of tranexamic acid in prevention of postpartum hemorrhage .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

140

Conditions

Postpartum Hemorrhage

Interventions

Tranexamic AcidDRUG

Tranexamic acid (Kepron, Amoun, Egypt) was given slowly intravenously over 10 minutes just before the skin incision of elective cesarean section to group A. Tranexamic acid injection was prepared by diluting 1g (10 mL) tranexamic acid into 20 ml of 5% glucose.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 42 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age of 28 weeks or more. * Chronic Hypertension. * Preeclapmsia -Eclampsia. * Multiple pregnancy. * Uterine Liomyomas. * Polyhydraminos. * Fetal macrosomia. * Associated Thrombocytopenia * History of postpartum hemorrhage. Exclusion Criteria: * Patients with rheumatic heart disease. * Patients with history Cardiac Valve Replacement. * Current or past history of DVT. * Women on any anticoagulant therapy. * Sensitivity to tranexamic acid * Pregnancies with any abnormally implanted or located placenta.

Outcomes

Primary Outcomes

prevention of postpartum hemorrhage in high risk group

assessment of intraoperative blood loss

Time frame: intraoperative

Data from ClinicalTrials.gov

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