The Biorhythm study aims to investigate the utility of new biomarkers (e.g. MR proANP, ST2) measured pre-procedure for the prediction of procedural success in patients with atrial fibrillation undergoing cardioversion or ablation.
This is a prospective, observational, multicentre study of patients with paroxystic or persistent atrial fibrillation scheduled to undergo cardioversion or ablation of AF in routine practice. Serum levels of MR proANP and ST2 pre-procedure will be measured to attempt to identify a threshold that carries prognostic value for procedural success (maintenance of sinus rhythm at one year).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
106
Pulmonary vein isolation by radiofrequency or cryoablation.
External electric shock delivery under general anesthesia.
University Hospital Jean Minjoz
Besançon, France
CHU François Mitterand
Dijon, France
CHU Brabois
Vandœuvre-lès-Nancy, France
Recurrent atrial fibrillation
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 12 months
Recurrent atrial tachycardia
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 12 months
Recurrent flutter
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 12 months
Recurrent atrial fibrillation
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 3 months
Recurrent atrial tachycardia
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 3 months
Recurrent flutter
Documented by ECG, Holter, telemetry, and lasting 30 seconds or more.
Time frame: 3 months
Palpitations
Any episode of palpitation occurring during follow-up
Time frame: 12 months
Hospitalization
Hospital admission related to atrial fibrillation, atrial tachycardia or flutter during follow-up
Time frame: 12 months
Repeat ablation
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Need for repeat ablation during follow-up in patients who underwent ablation of AF
Time frame: 12 months
Cardioversion
Need for electric or medical cardioversion during follow-up (all patients, regardless of initial intervention type)
Time frame: 12 months