Creatine Supplementation and Cognitive and Physical Tests

Vrije Universiteit Brussel14 enrolled

Overview

To assess whether brain creatine availability has an effect on cognition. To do so we will seek to increase brain creatine concentration via a creatine supplementation protocol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Healthy Creatine Supplementation

Interventions

CreatineDIETARY_SUPPLEMENT

Participants will have to supplement themselves with creatine for 7 days (20g/day).

Calcium lactateDIETARY_SUPPLEMENT

Participants will have to supplement themselves with calcium lactate for 7 days (elemental calcium: 0.780g/day).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy (No neurological illness including cardiovascular, renal, and endocrine disorder) * Male/female * No medication / supplements * Non-smoker * Low to moderately active * Between 18 and 35 years old Exclusion Criteria: * Injuries * Illness * Use of medication * Use of creatine in the last 3 months * History of head trauma or seizure * Vegetarian diet \[24\] * Not being able to follow up the restrictions and prohibitions for the subjects (see Restrictions and prohibitions for the subjects)

Locations (1)

Human Physiology and Sports Physiotherapy Research Group

Brussels, Belgium

Outcomes

Primary Outcomes

Cognitive performance - change in accuracy (%) during a 90-min cognitive task (i.e. Stroop task)

Accuracy (in %) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); Accuracy (%) will be assessed during both lab visits with a 90-min cognitive task; Accuracy during the 90-min task will be reported as mean accuracy during 8 blocks of 11min15sec

Cognitive performance - change in reaction time (milliseconds) during a 90-min cognitive task (i.e. Stroop task)

Reaction time (in milliseconds) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); Reaction time (RT) will be assessed during both lab visits with a 90-min cognitive task; RT during the 90-min task will be reported as mean RT during 8 blocks of 11min15sec

Secondary Outcomes

Physical performance - reaction time (milliseconds) during a 7-min visuomotor reaction time task

Reaction time (in milliseconds) will be assessed during a visuomotor reaction time task, this physical task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); visuomotor reaction time will be assessed during both lab visits with a 7-min visuomotor reaction time task.

Data from ClinicalTrials.gov

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