Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy

University Hospital, Caen20 enrolled

Overview

This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid endateriectomy, with reference to pathologic analysis of plaque components

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Carotid Artery Stenosis

Interventions

Sodium fluoride F-18 PET imagingDRUG

prior to surgical endarterectomy each patient will undergo sodium fluoride F-18 PET imaging

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age over 18 years old * Health care system affiliation * Referred to carotid endarterectomy * Symptomatic patients: * Carotid stenosis between 70 and 99% (NASCET criteria) * TIA or minor stroke attack (RANKIN ≤ 3) * Asymptomatic patients: * Carotid stenosis between 70 and 99% (NASCET criteria) * No symptoms * Patient who has been informed of the study and has given his/her informed consent Exclusion Criteria: * Contra indication to MRI * Renal failure (clearance \< 30ml/mn) * Patient with active inflammatory disease * History of cancer * Pregnancy or lactation * Patient with carotid disease treated by fibrinolysis * Patient under guardianship, or unable to understand the purpose of the study

Locations (1)

Caen University Hospital

Caen, France

RECRUITING

Outcomes

Primary Outcomes

carotid F18-NaF uptake

do the symptomatic patients have a higher F18-NaF uptake compared to asymptomatic patients? at pre-operative examination

Time frame: baseline

Secondary Outcomes

comparaison of F18-NaF PET and Carotid MRI

comparaison between F18-NaF uptake and MR features of plaque instability at pre-operative examination

Time frame: baseline

F18-NaF PET uptake

comparaison between F18-NaF uptake at pre-operative imaging

Time frame: baseline

histology

comparaison between histology at post-operative histologic analysis

Time frame: baseline

Central Contacts

Lucie Cameliere, MD

CONTACT

+33231065161 cameliere-l@chu-caen.fr

Alain Manrique, MD PhD

CONTACT

+33231470287 manrique@cyceron.fr

Data from ClinicalTrials.gov

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