Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion

Shahid Beheshti University of Medical Sciences74 enrolled

Overview

Patients with new onset retinal vein occlusion in less than 3 month whom has visual acuity less than 20/40 and central macular thickness more than 250micrometer and non perfused areas of retina more than 10 DD are included in over study and devided into 2 groups randomizely, Group A under gone 3 intravitreal injection of bevacizumab monthly and examine monthly for Visual acuity and central macular thickness, if in month four or more the CMT is more than 250 micrometer and the visual acuity is less than 8/10 the injection is repeated and follow up in this manner is continued until 9 months. Group B is as the same of group A but patients in this group undergone laser photocoagulation of retinal non perfused areas based on FAG wide field imaging . After 9 month follow up the outcomes such as Vusal acuity, Central macular thickness, intraocular pressure, neovascular formation are compared,

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Retinal Vein Occlusion With Macular Edema

Interventions

under gone 3 intravitreal injection of bevacizumab monthly and examine monthly for Visual acuity and central macular thickness, if in month four or more the CMT is more than 250 micrometer and the visual acuity is less than 8/10 the injection is repeatet and follow up in this manner is continued until 9 months.

intravitreal injection of bevacizumab+ targeted laserRADIATION

patients in this group undergone laser photocoagulation of retinal non perfused areas based on FAG wide field imaging . After 9 month follow up the outcomes such as Vusal acuity, Central macular thickness, intraocular pressure, neovascular formation are compared

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Center-involved macular edema secondary to RVO on clinical exam * Symptoms less than 3 months * BCVA= 20/40 or worse * Mean center point thickness \>250 μm * Media clarity, pupillary dilation, and subject cooperation sufficient for adequate fundus photographs One eye per participant is enrolled in the trial Exclusion Criteria: * Macular edema due to a cause other than CRVO * An ocular condition such that visual acuity would not improve from resolution of the edema (eg, foveal atrophy) * Substantial cataract estimated to have reduced visual acuity by \>3 lines * Prior treatment with intravitreal or peribulbar steroid injection * History of macular photocoagulation or PRP * Prior pars plana vitrectomy * Hx of Intraocular surgery (including cataract extraction) * uveitis, NVG, exudative AMD, diabetic retinopathy, any malignancy, optic neuropathy, amblyopia * vitreomacular traction or epiretinal membrane \*uncontrolled glaucoma ( \> 30mmHg with anti-glaucoma medications)

Locations (1)

Ophthalmic Research Center

Tehran, Iran

RECRUITING

Outcomes

Primary Outcomes

Visual acuity

Snellen chart

Time frame: Every month

Secondary Outcomes

macular thickness

OCT

Time frame: every month

Central Contacts

Alireza Ramezani, MD

CONTACT

009822591616 labbafi@hotmail.com

Data from ClinicalTrials.gov

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