This study will investigate the effects of aerobic exercise on mental states, cognition, BDNF, and long-term outcomes in patients with bipolar disorder.
Multiple cognitive impairments are common in patients with bipolar disorder. Preliminary evidence shows that aerobic exercise might have positive effects in enhancing cognition and improving clinical symptoms in patients with mood disorders. This randomized controlled trial will investigate short-term (1 months) effects of aerobic exercise on cognition and clinical symptoms as well as the long-term (12 months) effects on decreasing the recurrence rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
210
Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 months.
General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.
Guangzhou Brain hospital(Guangzhou Huiai Hospital)
Guangzhou, Guangdong, China
Changes in neurocognitive function
Changes in neurocognitive function measured by the MATRICS Consensus Cognitive Battery (MCCB) after three months (12 weeks) of aerobic exercise
Time frame: 12 months
Changes in neurocognitive function
Changes in neurocognitive function measured by the MATRICS Consensus Cognitive Battery (MCCB) after three months (12 weeks) of aerobic exercise
Time frame: Changes in neurocognitive function measured by the MATRICS Consensus Cognitive Battery (MCCB) after three months (12 weeks) of aerobic exercise
relapse rate
Relapses of depressive and/or hypo/manic episodes
Time frame: 12 months
depressive symptoms
depressive symptoms measured by Hamilton Depression Scale
Time frame: 4 weeks, 4 months, 12 months
manic symptom
manic symptom measured by Young Manic Rating Scale
Time frame: 4 weeks, 4 months, 12 months
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