Contrast-Enhanced Cone Beam Breast CT for Diagnostic Breast Imaging

Inclusion Criteria: * Female sex * Age 35 years or older * Any ethnicity * Have an abnormality detected by Breast Self Exam (BSE), or Clinical Breast Exam (CBE), or have an abnormality detected by an imaging modality. * Will undergo study imaging within four weeks from the date of diagnostic mammography, prior to breast biopsy (if needed). * Able to provide informed consent * Post-menopausal, surgically sterile, or effective birth control. For women of childbearing potential, negative pregnancy test or has signed pregnancy test waiver * If required by standard of care, eGFR \>45 within 48 hours to 6 weeks of CE-CBBCT exam Exclusion Criteria: * Pregnancy * Lactation * Unknown pregnancy status AND * has refused pregnancy testing and * has refused to sign a pregnancy test waiver * Women who are unable or unwilling to understand or to provide informed consent * Women with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker. * Women who are unable to tolerate study constraints. * Women who have received radiation treatments to the thorax or breast area for malignant and nonmalignant conditions, such as (but not limited to): * Treatment for enlarged thymus gland as an infant * Irradiation for benign breast conditions, including breast inflammation after giving birth * Treatment for Hodgkin's disease * Women who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * Women who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to): * Tuberculosis * Severe scoliosis Additional Exclusion Criteria Due To Contrast Injection: * Allergic to iodinated contrast material * Previous non-ionic contrast reaction * Any conditions below regardless of eGFR * Renal Disease * Chronic renal dysfunction * Renal Transplant (or waiting for a transplant) * One kidney or other birth defect * Polycystic Kidneys * Renal Tumor/Renal Cancer * History of liver failure/cirrhosis/liver transplant/pending liver transplant * Congestive heart failure * Multiple myeloma * Hyperthyroidism * Pheochromocytoma * Sickle Cell Disease * Asthma requiring daily use of inhaler Additional exclusion criteria due to machine limitations * Patient's body weight is over the limit of the scanner table (440 lbs or 200kg)