Cardiac Safety of Lansoprazole and Domperidon Combination

Inclusion Criteria: * GERD patients with BMI 18-33 kg/m2 * Patients with esophagitis class A-B according to Los Angeles classification Exclusion Criteria: * Patients whose long QT syndrome risk score \> 3. * Patients with family history of short or long QT syndrome. * Patients with Barrett's stricture, gastric outlet obstruction, malignancy, gastrointestinal system bleeding or any other upper gastrointestinal system pathology. * Patients whose Hiatus hernia is \> 3 cm. * Patients with uncontrolled or insulin dependent diabetes mellitus, symptomatic gallbladder stone, active or unhealed stomach or duodenum ulcer, Zollinger-Ellison syndrome, primary esophagus motility disorder, pancreatitis, inflammatory bowel disease, severe lung disease, chronic liver disease, uncontrolled kidney impairment, cancer (except skin cancer except melanoma), cerebrovascular disease, epilepsy. * Patients with history of heart failure, ventricular tachycardia, ventricular fibrillation, cardiac arrest, Torsades de pointes, bradycardia, sinus node dysfunction, heart attack, long QTc (\>460 ms). * Patients taken PPIs or H2-blockers within 7 days and prokinetic drugs within 3 days before entering the study. * Patients with major psychiatric disease. * Alcoholism and drug use. * Patients with pathologic laboratory tests; hemogram, sedimentation, CRP, thyroid functions tests, liver enzymes. * Malabsorption. * Immunosuppressive patients. * Patients taken cortisone. * Patients taken other drugs that prolong QT interval. * Patients taken drugs that need gastric acid for optimal absorption; ketoconazole, iron salts, digoxin, ampicillin esters, anticoagulants, antineoplastic agents, prostaglandin analogues, sucralfate, atazanavir, theophylline, tacrolimus, fluvoxamine, rifampisin, nefazodone and aprepitant. * Patients taken drugs carried with P-glycoprotein, indicated for heart diseases, AIDS/HIV or infection treatment. * Pregnancy or breast-feeding. * Patients taken drugs that may affect gastrointestinal system motility or acid release. * History of abdominal surgery (hysterectomy, abdominal hernia repair, caesarean cases may be included; cholecystectomy have to be excluded). * Patients with hypocalcemia and hypercalcemia * Patients taken NSAII drugs (paracetamol may be used up to 2 gr/day). * Patients taken antidepressants. * Hypersensitivity to study drugs.