Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
150
drug is intravenously infused to patients
drug is nasally given to patients
saline is given to patients intravenously
Xijing Hospital
Xi'an, Shaanxi, China
incidence of coughing
Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes
Ricker's agitation-sedation score
Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes
score of coughing
0=no coughing;1=intermittent coughing;2=continuous coughing
Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes
time to response to verbal command
Time frame: from end of infusing anesthetics to response to verbal command,averagely 20 minutes
time to extubation
Time frame: from end of infusing anesthetics to extubation,averagely 28 minutes
blood pressure before and after extubation
Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes
blood glucose before and after aneurysm embolism
Time frame: immediately before inserting coil and after finishing inserting coil,an average of 1 hour
blood lactate before and after aneurysm embolism
Time frame: immediately before inserting coil and after finishing inserting coil,,an average of 1 hour
Mini-mental state examination score
Time frame: 24 hours after surgery
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normal saline is given to patients nasally