The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy. The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment. The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
Study Type
OBSERVATIONAL
Enrollment
33
Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital
Aarhus, Denmark
Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital
Aarhus, Denmark
Changes in platelet function
Platelet function on day 3 compared with day 1 on ECMO. Measured by flow cytometry
Time frame: Platelet function measured day 1 and day 3 on ECMO
Changes in platelet aggregation
Comparison of platelet aggregation measured by whole blood impedance aggregometry (Multiplate).
Time frame: Platelet function measured every morning from day 1 to day 8 on ECMO (except weekends).
Immature platelet count
Estimation of platelet turn-over measured by a blood analyzer (Sysmex)
Time frame: Measured every morning from day 1 to day 8 on ECMO (except weekends)
Platelet count
Estimation of platelet count measured by a blood analyzer (Sysmex)
Time frame: Measured every morning from day 1 to day 8 on ECMO (except weekends)
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