Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology

Inclusion Criteria of patients : * For women with reproductively active age period: suitable contraceptive method and negative pregnancy test * Schizophrenia diagnosis (according to DSM 5) * Regular follow-up care at hospital * No change in antipsychotic medication (medication AND dosage) within at least six weeks * Patient into remission : constant dosage, out-patient and meeting Andreassen criteria * Who have given their informed consent before participating in the study. * Physical examination without significant clinical physical anomaly * No serious somatic pathology * Affiliates or entitled to a social security scheme Exclusion Criteria of patients : * For women with reproductively active age period: no suitable contraceptive method (oral, hormonal, intramuscular, intrauterine device, or surgical) * Pregnancy or breastfeeding * Not meeting schizophrenic criteria according to DSM 5 or presenting resistant schizophrenic criteria according Kane criteria * Presenting a serious somatic disorder or neurological (particularly Parkinson disease, epilepsy, tardive dyskinesia) * Cardiovascular, hepatic or serious renal diseases * Contraindication to MRI examination, particularly ocular or intracranial metallic foreign object,pacemaker, artificial heart valve, surgical clip * Claustrophobia, significant tatoo in the high part of the body, IUD incompatible with MRI 3Tesla * Alcohol or drug addiction, within the last year * Recruited in other clinical trial or exclusion period from previous trial. * Susceptibility to self-harm behaviour according to investigator Inclusion Criteria of Related volunteers : * Age, gender and socio-educational level similar to recruited patients * Who have given their informed consent before participating in the study. * First degree relative of schizophrenic patient diagnosed according DSM IV criteria * No schizophrenia diagnosis according DSM IV criteria * No psychiatric history and free of psychotropic drugs/treatment * Physical examination without significant clinical anomaly * Affiliates or entitled to a social security scheme Exclusion Criteria of Related volunteers : * For women with reproductively active age period: no suitable contraceptive method (oral, hormonal, intramuscular, intrauterine device, or surgical) * Pregnancy or breastfeeding * Presenting somatic, neurological or psychiatric disorder * Alcohol or drug addiction, within the last year * Recruited in other clinical trial or exclusion period from previous trial. * Contraindication to MRI examination, particularly ocular or intracranial metallic foreign object, pacemaker, artificial heart valve, surgical clip * Claustrophobia, significant tatoo in the high part of the body, IUD incompatible with MRI 3Tesla Inclusion Criteria of Healthy volunteers : * Age, gender and socio-educational level similar to recruited patients * Who have given their informed consent before participating in the study. * No schizophrenia diagnosis according DSM IV criteria * No personal or family history of psychiatric disorders * Free of psychotropic drugs/treatment * Physical examination without significant clinical anomaly * Affiliates or entitled to a social security scheme Exclusion Criteria of Healthy volunteers : Beside the absence of schizophrenia diagnosis, healthy volunteers should meet the same exclusion criteria as patients