Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

Changhai Hospital260 enrolled

Overview

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. 3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. 4L-group received 4bags of PEG and were instructed to drink 2 L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Enrollment

260

Conditions

Bowel Preparation Scale Adenoma Detection Rate

4L Polyethylene GlycolDRUG

4L group received double-dose PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes.

3L Polyethylene GlycolDRUG

3L group were instructed to drink 1L PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Outpatients aged 18-75 years 2. Referred for routine diagnostic colonoscopy 3. Patients who have signed inform consent form Exclusion Criteria: 1. pregnancy or breastfeeding 2. allergy to purgatives 3. suspected intestinal obstruction, stricture, or perforation 4. hemodynamic instability 5. impaired swallowing reflex or mental status 6. severely medical status, such as New York Heart Association grade III or grade IV congestive heart failure and severe renal failure 7. history of oesophagus、stomach 、duodenum、small intestine or colorectal surgery 8. participation declined.

Outcomes

Primary Outcomes

the Boston Bowel Preparation Scale

The primary end point of the study was adequate bowel preparation quality de ned as a BBPS total score of ≥6 with all segment scores ≥2

Time frame: 2 days

Secondary Outcomes

Polyp detection rate

The secondary end point of the study included polyp detection rate

Time frame: 2 days

Adenoma detection rate

The secondary end point of the study included adenoma detection rate

Time frame: 2 days

The mean number of incremental adenomas

It was a new metric called ADR-Plus, the mean number of incremental adenomas after the fist.

Time frame: 2 days

Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts