DLAAG in the Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome With Blast Excess

Inclusion Criteria: 1. corresponding to the AML (except M3) or high-risk MDS diagnostic criteria, with any of the following circumstances: ①secondary AML patients (including AML secondary to MDS) ②corresponding to refractory AML diagnostic standard ( relapsed refractory acute myeloid leukemia Chinese guidelines(2017 Edition): Refractory AML diagnostic criteria: invalid after standard treatment 2 cycles of untreated cases; consolidation therapy after CR and then recurrence within 12 months; recurrence after 12 months and then invalid after conventional chemotherapy ; relapse of ≥ 2 times ; extramedullary leukemia continued existence. ③corresponding to recurrent AML diagnostic criteria (relapsed refractory acute myeloid leukemia China guidelines (2017 Edition): peripheral blood leukemia cells or bone marrow progenitor cells appear again \> 0.050 after CR (with the exception of bone marrow regeneration after consolidation chemotherapy and other reasons) or leukemia cells infiltration appear in extramedullary ④corresponding to MDS refractory anemia with blasts excess (RAEB) diagnosis standards 2. Age ≥18 years old 3. Eastern Cooperative Oncology Group(ECOG) score 0-3 4. Expected survival ≥8 weeks 5. Patients must be able to understand and be willing to participate in this study, and signed informed consent Exclusion Criteria: 1. acute promyelocytic leukemia (M3 type) 2. Other types of MDS patients except RAEB 3. with other advanced malignant tumors 4. patients with uncontrolled severe infection, and can not tolerate chemotherapy with other serious underlying diseases 5. patients with heart failure: ejection fraction (EF) \< 30%, New York Heart Association(NYHA) standard, cardiac insufficiency in class II or above