Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)

Central Hospital, Nancy, France63 enrolled

Overview

Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Stiffness, Aortic Cardiac Remodeling, Ventricular Vascular Remodeling Magnetic Resonance Imaging, Functional Athletes

Eligibility

Sex: MALEMin age: 18 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * to be enrolled in a social security plan. * to have a BMI between 18,5 and 25 kg/m² * to have received full information on the organization of the research and having signed its informed consent * to have carried out a clinical screening adapted to the research \*\*\* Triathlete group: * to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof), * to participate in 2018 in a long distance triathlon, i. e. at least distance L * to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective \*\*\*Control group: * to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.). Exclusion Criteria: * Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code * Cardiovascular history including Ii.e. known heart rhythm disorders * Chronic disease: diabetes, high blood pressure... * Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist, * Active smoking, even if occasional * Contraindication to MRI

Outcomes

Primary Outcomes

Aortic compliance in triathletes in mm2/mmHG

aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio

Time frame: at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)