Impact of Correction of Vitamin D Deficiency in Oxidative Stress in Patients With Prediabetes (VICOX)

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran31 enrolled

Overview

The investigators aim to determine the effect of the correction of vitamin D in vitamin D deficient patients (\<15ng/ml) in oxidative stress and insulin resistance in patients with impaired glucose tolerance. Vitamin D deficiency has been associated with chronic low-grade inflammation, diabetes mellitus type 2, cardiovascular risk and increased prevalence of coronary heart disease, cerebrovascular disease and myocardial infarction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Vitamin D Deficiency Glucose Intolerance Oxidative Stress Insulin Resistance

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women, 18 to 70 years, glucose intolerance (post-2 hour 75-grams glucose load \> or equal 140 mg/dl), 25-hydroxy vitamin D concentration \< or equal 15 ng/ml Exclusion Criteria: * Diabetes, systemic inflammatory disorders, treatment with statins, metformin or fibrates, renal insufficiency, intestinal malabsorption

Outcomes

Primary Outcomes

Change in anti-oxidant capacity measured in serum

Change in serum anti-oxidant capacity after one month

Time frame: One month

Secondary Outcomes

Change in homeostasis model assessment (HOMA) index measured in serum

Change in homeostasis model assessment (HOMA) index after one month