Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans

University of Sao Paulo10 enrolled

Overview

This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.

Autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. Treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. Thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Alveolar Bone Atrophy Bone Resorption

Interventions

ControlPROCEDURE

Control side will receive only perforations on recipient site, which is the conventional technique for bone blocks graft.

AcidPROCEDURE

Test side will receive treatment with citric acid (10%) for 30s at bone block surface and recipient site

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of atrophic anterior maxilla (width 1.5 to 4 mm) * Absence of active periodontal disease. * Enough bone width on donor sites (oblique line or ment) Exclusion Criteria: * Systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation * Smokers * Pregnant women * Patients receiving radiotherapy or chemotherapy * Patients using bisphosphonates

Locations (1)

Bauru School of Dentistry

Bauru, São Paulo, Brazil

Outcomes

Primary Outcomes

Clinical bone block consolidation

Absence of fibrous tissue by clinical observation

Time frame: 5 months

Computerized tomography images bone block consolidation

Absence of images compatible to fibrosis in cone beam computerized tomography images

Time frame: 5 months

Histological bone block consolidation

Absence of fibrous tissue between bone block and recipient site in histological images.

Time frame: 5 months

Secondary Outcomes

Bone width

Measurement of bone width in mm on cone beam computerized tomography. Ideal if \>6 mm.

Time frame: 5 months

Data from ClinicalTrials.gov

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