The purpose of this study is to evaluate the effects of BMS-986231 on systolic and diastolic parameters in patients with heart failure and low ejection fraction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
49
Orange County Research Center
Tustin, California, United States
Northwestern Medicine
Chicago, Illinois, United States
Mean Stroke Volume Index (SVI) Derived From the Velocity Time Integral at the Left Ventricular Outflow Tract (LVOT VTI) at the End of the 5-hour Infusion of BMS-986231, Versus Placebo
The objective is to evaluate the effects of BMS-986231 on the left ventricular (LV) systolic function by stroke volume index (SVI) assessed by echocardiography compared to placebo.
Time frame: at the end of the 5-hour infusion
Mean SVI Derived From LVOT VTI at the End of the 5-hour Infusion of BMS-986231, Versus NTG
The objective is to evaluate the effects of BMS-986231 on the left ventricular (LV) systolic function by stroke volume index (SVI) assessed by echocardiography compared to NTG.
Time frame: at the end of the 5-hour infusion
Mean LVEF, Computed by Simpson's Method at the End of the 5-hour Infusion of BMS-986231, Versus Placebo and NTG
Evaluate the effects of BMS-986231 on selected other left ventricular systolic and diastolic indices compared to placebo and NTG: LV ejection fraction
Time frame: at the end of the 5-hour infusion
Mean Cardiac Power Index at the End of the 5-hour Infusion of BMS-986231, Versus Placebo and NTG
Evaluate the effects of BMS-986231 on selected other left ventricular systolic and diastolic indices compared to placebo and NTG: Mean LV power index
Time frame: at the end of the 5-hour infusion
Mean Diastolic Indices: E/A and E/e' Ratio at the End of the 5-hour Infusion of BMS-986231, Versus Placebo and NTG
Evaluate the effects of BMS-986231 on selected other left ventricular systolic and diastolic indices compared to placebo and NTG: Diastolic function
Time frame: at the end of the 5-hour infusion
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Indiana University School of Medicine-Indianapolis
Indianapolis, Indiana, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
Duke Advanced Heart and Lung Failure Clinic
Durham, North Carolina, United States
Inova Heart and Vascular Institute
Falls Church, Virginia, United States
Local Institution
Nagoya, Aichi-ken, Japan
Local Institution
Kawasaki, Kanagawa, Japan
Local Institution
Suita-shi, Osaka, Japan
Local Institution
Groiningen, Netherlands
...and 8 more locations
Mean Diastolic Indices: Annular e' Velocity at the End of the 5-hour Infusion of BMS-986231, Versus Placebo and NTG
Evaluate the effects of BMS-986231 on selected other left ventricular systolic and diastolic indices compared to placebo and NTG: Diastolic function
Time frame: at the end of the 5-hour infusion
Mean LV Global Longitudinal Strain, Computed Using STE at the End of the 5-hour Infusion of BMS-986231, Versus Placebo and NTG
Evaluate the effects of BMS-986231 on selected other left ventricular systolic and diastolic indices compared to placebo and NTG: LV global longitudinal strain
Time frame: at the end of the 5-hour infusion