LOD Before IVF/ICSI in PCOS Patients With High AMH

Mansoura University120 enrolled

Overview

To evaluate the effect of performing laparoscopic ovarian drilling (LOD) before proceeding to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the cycle outcomes in polycystic ovarian syndrome (PCOS) patients with high antimullerian hormone (AMH) levels

Retrospective case-control study of PCOS women with high serum AMH level (≥ 7 ng/ml) who were subjected IVF/ICSI. Women underwent LOD in the preceding 3 months prior to IVF/ICSI (study group) will be compared with a control group of women who did not underwent LOD (control group)

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Infertility Polycystic Ovarian Syndrome

Interventions

LODPROCEDURE

Women underwent LOD in the preceding 3 months prior to IVF/ICSI

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * PCOS women subjected to COS through fixed gonadotropin releasing hormone (GnRH) antagonist protocol with final triggering of oocyte maturation by GnRH agonist (GnRHa) * Elevated serum AMH level (≥ 7 ng/ml) Exclusion Criteria: * Age \< 18 years or \> 35 years * Body mass index (BMI) \< 19 kg/m2 or \> 35 kg/m2 * Use of cabergoline therapy or coasting to minimize the risk of OHSS

Locations (1)

Fertility Care Unit (FCU) in Mansoura University Hospital

Al Mansurah, Dakahlia Governorate, Egypt

Outcomes

Primary Outcomes

Number of oocytes retrieved

Number of collected oocytes during oocyte retrieval

Time frame: 36-38 hours after triggering of oocyte maturation

Oocyte maturity rate

Calculated for each woman by dividing the number of mature oocytes (MII oocytes) by the total number of oocytes retrieved

Time frame: Within one hour after oocyte retrieval

Fertilization rate

Calculated for each couple by dividing the number of fertilized oocytes by the number of injected (or inseminated) oocytes

Time frame: 20-24 hours after injection (or insemination)

Secondary Outcomes

Clinical pregnancy rate

Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures

Time frame: 6 weeks after embryo transfer

Implantation rate

Number of gestational sacs on TVS scan at 4-6 weeks after ET divided by the number of transferred embryos

Time frame: 6 weeks after embryo transfer

Incidence of early OHSS

Incidence of OHSS within 9 days of final triggering of oocyte maturation

Time frame: Within 9 days of final triggering of oocyte maturation

Data from ClinicalTrials.gov

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