The Relationship Between Physical Activity and Radiographic Osteoarthritis Worsening

Peking University People's Hospital1,200 enrolled

Overview

Wuchuan Osteoarthritis Study is a population-based longitudinal study of natural history of knee osteoarthritis and its risk factors. At baseline and follow-up visits, IPA-Q questionnaire and a radiographs at tibiofemoral (TF) joints will be taken in order to assess the relationship between physical activity and radiographic osteoarthritis worsening.

1025 residents aged ≥ 50 years will be recruited using door-to-door enumeration in randomly selected rural communities in Wuchuan, China, and will be followed in 3 years. At baseline and follow-up visits, subjects will complete a home interview (including, but not limited to, socio-demographic factors, physical activity level using IPA-Q questionnaire,WOMAC questionnaire) and have a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints. Radiographic osteoarthritis (ROA) worsening for a knee is defined if its Kellgren and Lawrence (K/L) grade increases by at least 1 grade except for the change from 0 to 1 during follow-up. The relationship between level of physical activity and ROA worsening will be assessed.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Osteoarthritis, Knee

Interventions

level of physical activityOTHER

According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. people aged 50 or over 2. Wuchuan permanent resident population Exclusion Criteria: 1. patients with rheumatoid arthritis 2. the disabled 3. patients with mental disorders 4. laid up for malignant tumor 5. people who live or work outside for more than half a year

Outcomes

Primary Outcomes

worsening of radiographic osteoarthritis

The tibiofemoral radiograph of both knee joint will be taken at baseline and in 3 years. Knee radiographs will be read by one investigator according to Kellgren and Lawrence (K/L) criteria. A knee will be defined as ROA worsening if its K/L grade increased by at least 1 grade except for the change from 0 to 1 during follow-up.

Time frame: 3 years after enrollment

Secondary Outcomes

The Western Ontario and McMaster Universities Osteoarthritis Index

The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) will be assessed at baseline and in 3 years, from which symptoms of patients can be estimated.

Time frame: 3 years after enrollment

Central Contacts

Chutong Lin

CONTACT

+86 15652930253 chutonglin@126.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.