Prolonged Multimodal Analgesia for Post-Discharge Pain Control After Primary Total Hip Arthroplasty

Rothman Institute Orthopaedics228 enrolled

Overview

This is a prospective, three-arm, comparative study with a provider-crossover design. The first arm will comprise the standard of care pain regimen after discharge, which comprises PRN oxycodone, tramadol, and acetaminophen. The second arm will comprise a multimodal pain regimen; however, patients will still be routinely provided PRN oxycodone and tramadol to use on an as needed basis. The third arm will comprise a multimodal pain management protocol, which does not routinely allow for opioid consumption. However, patients will be provided a one week supply of oxycodone and tramadol for emergency pain relief only.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

228

Conditions

Osteoarthritis, Hip

Interventions

Multi-modal with as needed oxycodone and tramadol provided for break-through pain

Multi-modal with one week of opioids offeredDRUG

Multi-modal with only one week of oxycodone and tramadol provided for emergency pain relief only

Standard of CareDRUG

This arm follows standard of care post-operative pain management with oxycodone, tramadol, and acetametophin

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing unilateral, primary cementless THA with underlying diagnosis of osteoarthritis. * ASA I - III * Spinal anesthesia * Male and Female over 18 who are willing and able to provide informed consent Exclusion Criteria: * Opioid use within 3 months prior to surgery * General anesthesia * Non-english speaking * ASA IV or greater * Allergy/contraindications to protocol medications * Renal insufficiency with Cr \> 2.0 or hepatic failure * Sensory/motor disorder involving the operative limb * Planned or unplanned discharge to rehab * Length of stay \>3 days * Revision or conversion THA * Cigarette smokers

Locations (1)

Rothman Institute

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

total opioid consumption

Time frame: total consumption calcuated from surgery date through 30 days post-op

Pain

Pain as reported by Visual Analog Scale

Time frame: 30 days post-operative

Data from ClinicalTrials.gov

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