Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

Kecioren Education and Training Hospital135 enrolled

Overview

Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing. In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

135

Conditions

Tranexamic Acid Epistaxis Nasal Packing

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with anterior epistaxis older than 18 year and accept to participate in the study Exclusion Criteria: * Patients younger than 18 years * Patients who used anticoagulation therapy * Patients who have hemodynamically instability * Traumatic epistaxis * Patients who have known bleeding disorder

Outcomes

Primary Outcomes

Success rate of interventions to stop bleeding

Percentages of numbers of patients who have stopped bleeding within first 15 minutes after nasal compression or Merocel packing

Time frame: First 15 minutes

Numbers of patients who needs rescue treatment

In patients who have unstoppable epistaxis within 15 minutes, Merocel packing will be applied as a rescue treatment. Numbers of these patients will be recorded.

Time frame: After 15 minutes first intervention method.

Secondary Outcomes

Re-bleeding

Frequency of re-bleeding within first 24 hours.

Time frame: 24 hour