Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium

Institut Mutualiste Montsouris50 enrolled

Overview

The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control. Hypothesis is that prothesis implantation will decrease levels of microparticles circulating in blood circulation because of occluding of the left atrium .

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atrial Fibrillation

Interventions

blood samplingOTHER

* atrial fibrillation group:before Percutaneous Occluding of the Left Atrium, at hospital discharge and at J45 follow up * control group:before coronary angiography and at hospital discharge.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: atrial fibrillation group: * high embolic risk (CHADS-VASC2 score ≥4) * formal and final contraindication to anticoagulant therapy * no heart thrombus on ETO and TDM before percuraneous occluding control group: * suspicion of stable coronary artery disease, coronary angiography scheduled and double platelet aggregation (clopidogrel and aspirine) Exclusion Criteria: for both groups * congestive heart failure, severe aortic stenosis, EP or TVP early.

Locations (1)

Institut Mutualiste Montsouris

Paris, France

RECRUITING

Outcomes

Primary Outcomes

levels of microparticles expressing phosphatidylserine in atrial fibrillation group

blood samples analized by flow cytometry

Time frame: 45 days after Percutaneous Occluding of the Left Atrium.

Central Contacts

Nicolas AMABILE, doctor

CONTACT

+33 1 56 61 nicolas.amabile@imm.fr

Isabelle SAURET

CONTACT

+33 1 56 61 67 05 isabelle.sauret@imm.fr

Data from ClinicalTrials.gov

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