Removal of Beta Blocker Drugs by Hemodialysis

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's8 enrolled

Overview

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Chronic Kidney Diseases

Interventions

Beta blockerDRUG

Beta blockers are administered as described in arms.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * at least 18 years of age, receiving hemodialysis three times per week for at least 90 days. Exclusion Criteria: * gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).

Outcomes

Primary Outcomes

Dialytic Clearance

Dialytic clearance calculated by the recovery clearance method

Time frame: Through study completion, average of one year.

Secondary Outcomes

Dialytic Clearance

Dialytic clearance calculated by the arteriovenous difference method

Time frame: Through study completion, average of one year.

Data from ClinicalTrials.gov

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