STEMI Cool Pilot Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)

Inclusion Criteria: 1. The patient is \>= 18 years of age. 2. The patient must have symptoms consistent with AMI (i.e. chest pain, arm pain, etc.) and unresponsive to nitroglycerin, with symptoms beginning greater than 60 minutes but less than 4.5 hours prior to presentation at Hospital. 3. Evidence of Acute Anterior MI with ST-segment elevation of \>= 0.2 mV in two or more anterior contiguous precordial leads (V1-V4), as confirmed by ECG at baseline. 4. The patient is eligible for primary PCI. 5. The patient's condition and site workflow allow for the feasibility of implementing the cooling protocol within trial protocol specific requirements. 6. The patient or patient's legal representative is willing to provide written, informed consent to participate in this clinical trial. Exclusion Criteria: 1. The patient has had a previous myocardial infarction. 2. The patient is experiencing cardiogenic shock, systolic blood pressure \[SBP\] \<100 mmHg, HR\>100 bpm and arterial oxygen saturation (pulse oximetry) \<= 92% without additional oxygen. 3. The patient has known history of Congestive Heart Failure (CHF), hepatic failure, end stage kidney disease or severe renal failure (clearance \< 30ml/min/1.73m²). 4. The patient is presenting with resuscitated cardiac arrest, atrial fibrillation, or Killip risk stratification class III through IV. 5. The patient has an aortic dissection or requires an immediate surgical or procedural intervention other than PCI. 6. The patient is febrile (temperature \> 37.5 °C) or has experienced any infection in the last 5 days. 7. The patient has a known previous CABG. 8. The patient has a known recent stroke within 90 days of admission. 9. Cardio-pulmonary decompensation that has occurred en route to the hospital or, in the opinion of the physician, that is imminent or likely to occur following presentation to the clinical site. 10. Contraindications to hypothermia, such as patients with known hematologic dyscrasias which affect thrombosis (e.g., cryoglobulinemia, sickle cell disease, serum cold agglutinins) or vasospastic disorders (such as Raynaud's or thromboangitis obliterans). 11. Any contraindication to cardiac Magnetic Resonance Imaging (MRI), or any implant in the upper body which may cause artifacts on cardiac MRI imaging. 12. The patient has a known hypersensitivity or contraindication to aspirin, heparin, or anaphylaxis to contrast media, which cannot be adequately pre-medicated. 13. The patient has a known history of bleeding diathesis, coagulopathy, cryoglobulinemia or sickle cell anemia, or will refuse blood transfusions. 14. The patient has a height of \<1.5 meters (4 feet 11 inches). 15. The patient has a known hypersensitivity or contraindication to Buspirone hydrochloride or Meperidine and/or has been treated with a monoamine oxidase inhibitor in the past 14 days. 16. Patient has a known history of untreated hypothyroidism, Addison's disease, benign prostatic hypertrophy, or urethral stricture that in the opinion of the physician would be incompatible with Meperidine administration. 17. The patient has an Inferior Vena Cava filter in place (IVC). 18. The patient has an anticipated life expectancy of \<1 year. 19. The patient has a known, unresolved history of drug use or alcohol dependency, or lacks the ability to comprehend or follow instructions. 20. The patient is currently enrolled in another investigational drug or device trial. 21. The patient is apprehensive about or unwilling to undergo the required MRI imaging at follow-up, has a documented or suspected diagnosis of claustrophobia, or has a Gadolinium allergy. 22. The patient has received thrombolytic therapy en route to the hospital. 23. The patient has received any oral P2Y12 inhibitors prior to enrollment. 24. The patient shows clinical evidence of spontaneous reperfusion as observed symptomatically and/or from ECG findings (partial or complete ST resolution in ECG prior to informed consent and randomization). 25. The patient is a vulnerable subject, for instance, a person in detention (i.e., prisoner or ward of the state). 26. The patient is a female who is known to be pregnant or expected to become pregnant. 27. In the opinion of Investigator or designee the patient is not willing and able to comply with all the study requirements.