The aim of this clinical study is to investigate and compare the postprandial glycemic response to three different meal types rich in carbohydrates, that is, white pasta, high protein pasta and white rice consumed by individuals with T1DM.
The aim of this clinical study is to investigate and compare the postprandial glycemic response to three different meal types rich in carbohydrates, that is, white pasta, high protein pasta and white rice consumed by individuals with T1DM and to demonstrate that: 1. The choice of carbohydrates consumed significantly affects the postprandial glycemic profile in people with type 1 diabetes and 2. The consumption of high protein pasta will present a tighter postprandial glycemic response. Previous studies have evaluated the effect of white pasta and rice on postprandial glycemic response in people with type 1 diabetes. With this study, we aim to expand upon these findings by ensuring that the results can still be applied to more recent commercial food products (pasta, rice), but especially to evaluate the effect of high-protein pasta when compared to regularly consumed carbohydrates (white pasta, white rice). After consuming the study meal, subjects will participate in an education session (a 2 hour class per each meal challenge session). Classes will be taught by a registered dietician and diabetes \& exercise expert and, as appropriate, a culinary instructor.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
14
Regular pasta (Approximately 42 grams carbohydrate per meal)
High protein pasta (Approximately 38 grams carbohydrate per meal)
White rice (Approximately 43 grams carbohydrate per meal)
Sansum Diabetes Research Institute
Santa Barbara, California, United States
Delta glucose (maximum rise from baseline glucose) mg/dL
Delta glucose (maximum rise from baseline glucose) from the start of the meal to the peak continuous glucose monitoring (CGM) glucose reading (mg/dL) during the 5-hour postprandial window, compared between the three meal types.
Time frame: 5 hours
Incremental area under the curve (area)
Incremental area under the curve (iAUC) glucose level for the 5 hour postprandial period adjusted for baseline glucose at the start of the meal.
Time frame: 5 hours
Time to peak glucose level (minutes)
Time to peak glucose level (in minutes from intervention)
Time frame: 5 hours
percent time glucose <70 mg/dL
In case of postprandial hypoglycemia, percent time glucose \<70 mg/dL for the 5 hour postprandial period will be evaluated.
Time frame: 5 hours
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