This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.
Fabry disease is a rare disease and part of the group of lysosomal storage disorders. Natural history of Fabry disease has proven poor survival to ages \>50 years outlining the importance to evaluate cardiac symptoms and outcomes of patients with Fabry disease. This study is a prospective cohort study and observes patients since 2001. Through this long-term experience and the relative high number of patients this study is suggested to help estimating the risk of cardiac arrhythmias and sudden cardiac death (SCD) as well as death or heart transplantation due to terminal heart failure. All patients in treatment in the Fabry Center Wuerzburg (FAZiT) are included in this study if informed consent is provided.
Study Type
OBSERVATIONAL
Enrollment
650
Wuerzburg University Hospital
Würzburg, Bavaria, Germany
RECRUITINGCardiac death
Patients sustaining cardiac death
Time frame: From date of inclusion until the date of first documented event, up to the year 2032
Heart transplantation
On the basis of severe cardiac damage heart transplantation is needed
Time frame: From date of inclusion until the date of first documented event, up to the year 2032
Malign Arrhythmias
Patients suffering any malign arrhythmias
Time frame: From date of inclusion until the date of death, up to the year 2032
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