The purpose of this study is to evaluate the absorption of BMS-986205 into the bloodstream of healthy volunteers, when administered as an intact tablet taken orally, or as a crushed tablet taken orally with soft food, or as a crushed tablet suspension taken via a nasogastric (NG) tube. Eligible participants will be randomly assigned to 1 of 4 treatment sequences and will receive a single dose of BMS-986205 twice during the course of the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Single 100 mg dose on Day 1 and Day 15
PPD Austin Clinic
Austin, Texas, United States
Maximum observed plasma concentration (Cmax) of single 100 mg dose of BMS-986205 administered orally as crushed tablet on soft food compared to intact tablet administered orally.
Measured by plasma concentration.
Time frame: Up to 22 days
Maximum observed plasma concentration (Cmax) of single 100 mg dose of BMS-986205 administered via nasogastric (NG) tube as crushed tablet suspension compared to intact tablet administered orally.
Measured by plasma concentration.
Time frame: Up to 22 days
Area under the plasma concentration time curve from time zero to 168 hours after dosing (AUC[0-168]) of single 100 mg dose of BMS-986205 administered orally as crushed tablet on soft food compared to intact tablet administered orally.
Measured by plasma concentration.
Time frame: Up to 22 days
Area under the plasma concentration time curve from time zero to 168 hours after dosing (AUC[0-168]) of single 100 mg dose of BMS-986205 administered via nasogastric (NG) tube as crushed tablet suspension compared to intact tablet administered orally.
Measured by plasma concentration.
Time frame: Up to 22 days
Incidence of non-serious Adverse Events (AEs).
Safety and tolerability as measured by incidence of non-serious AEs.
Time frame: Up to 22 days
Incidence of Serious Adverse Events (SAEs).
Safety and tolerability as measured by incidence of SAEs.
Time frame: Up to 22 days
Number of participants with clinical laboratory abnormalities.
Time frame: Up to 22 days
Number of participants with vital sign abnormalities.
Time frame: Up to 22 days
Number of participants with electrocardiogram (ECG) abnormalities.
Time frame: Up to 22 days
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