Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy. According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry). This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study. The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter. Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication. Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
69
walking speed, grip strength and BIA. QAPPA questionnaire (validated in French in the elderly) and the objective measurement of the time of activity and rest on a week per wrist actimeter. Comprehensive Geriatric Assessment
Caen University Hospital
Caen, France
RECRUITINGAPHM
Marseille, France
RECRUITINGRouen UH
Rouen, France
SUSPENDEDpost-operative morbidity
evaluated according to Clavien-Dindo classification
Time frame: at 30 days
post-operative mortality
Time frame: at 30 days
post-operative complications
Impact of dependancy (PS / ADL / IADL)
Time frame: 8 months
post-operative complications
physical activity scores (QAPPA) Questionnaire d'activité physique pour les personnes âgées in French validated in French population - total score is used
Time frame: 8 months
post-operative complications
physical performance (PBP)
Time frame: 8 months
post-operative complications
fatigue (BFI) Brief Fatigue Inventory questionnaire
Time frame: 8 months
post-operative complications
history of fall
Time frame: 8 months
post-operative complications
pain (visual analogic scale for pain 0 to 10)
Time frame: 8 months
post-operative complications
hours of mobility (actimetry)
Time frame: 8 months
post-operative complications
hours of daily rest (actimetry) measured during 3 consecutives days
Time frame: 8 months
post-operative complications
Actimetry
Time frame: 8 months
post-operative complications
nutritional status (nutritional grade 2 or 4 according to SFNEP Société Francophone Nutrition Clinique et Métabolisme )
Time frame: 8 months
post-operative complications
cognitive status (normal or not)
Time frame: 8 months
post-operative complications
polymedication (≥5 / day)
Time frame: 8 months
post-operative complications
comorbidities (updated charlson)
Time frame: 8 months
post-operative complications
inappropriate prescriptions (STOPP)
Time frame: 8 months
impedancemetric value
Concordance of values (attribution of sarcopenic / non-sarcopenic groups) with impedancemetric value
Time frame: 2 months
sarcopenic status
evolution of sarcopenic status
Time frame: between baseline; preoperative and at 6 months post-operative
quality of life scores
EORTC QLQ-ELD14 (assessment of health-related quality of life elderly patients with cancer with 14 items)
Time frame: preoperative and 6-month post-operative
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