Food Preference Following Bariatric Surgery

Imperial College London34 enrolled

Overview

Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity

Interventions

Food PreferenceBEHAVIORAL

Buffet meal to assess food preference

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Surgical and non-surgical groups: A) Bariatric surgery B) Controls with no history of bariatric surgery 2. Independently mobile 3. Capacity to consent to participate 4. \>18 years of age Exclusion Criteria: 1. Pre-operatively: significant dysphagia, gastric outlet obstruction or anything that prevents subjects from eating a meal. 2. Post-operatively: significant and persistent surgical complications or anything that prevents subjects from eating a meal. 3. Systemic or gastrointestinal condition which may affect food intake or preference, including: i) pregnancy or ii) breast feeding. 4. Active and significant psychiatric illness including substance misuse 5. Significant cognitive or communication issues 6. Medications with documented effect on food intake or food preference 7. History of significant food allergy and certain dietary restrictions 8. History of liver disease or pancreatitis 9. History of bradyarrythmia or congestive cardiac failure group) 10. Use of medications with potential serious interactions with Octreotide

Locations (1)

University College Dublin

Dublin, Ireland

Outcomes

Primary Outcomes

Total Food Intake (Lunch Buffet) at 24 Months

Determine the effect of RYGB on total food intake from an ad libitum lunch buffet

Time frame: 24 months

Change in Absolute Intake of Fat

Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet

Time frame: 24 months

Change in Absolute Intake of Carbohydrates

Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet

Time frame: 24 months

Change in Absolute Intake of Sugar

Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet

Time frame: 24 months

Change in Absolute Intake of Protein

Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet

Time frame: 24 months

Data from ClinicalTrials.gov

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