Chloroprocaine Spinal for Outpatient Knee Surgery

Phase 2TerminatedNCT03365752

Hospital for Special Surgery, New York39 enrolled

Overview

Outpatient knee surgeries with duration of less than one hour pose a challenge to the use of spinal anesthesia given that traditional agents remain in effect for 2-3 hours, thus creating a mismatch between length of surgery and anesthetic resolution. The investigators hypothesize that the use of chloroprocaine can combine the benefits of a short spinal anesthetic while avoiding the side effects of a general anesthetic, thus promoting earlier discharge.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Knee Arthroscopy

Interventions

ChloroprocaineDRUG

A spinal anesthetic with 2% chloroprocaine (2cc or 40 mg) will be performed

MepivacaineDRUG

A spinal anesthetic with 1.5% Mepivacaine (3cc or 45 mg) will be performed

General AnestheticsDRUG

General anesthetics will be administered intravenously

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for a knee arthroscopy that is anticipated to be less than one hour * Age 18 to 80 years * Ability to follow study protocol * English speaking Exclusion Criteria: * Hepatic or renal insufficiency * Younger than 18 years old and older than 80 * Allergy or intolerance to one of the study medications * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Chronic opioid use (taking opioids for longer than 3 months) * Patients unable to undergo a spinal anesthetic or Laryngeal Mask Airway (LMA)/GA or patient refusal to spinal anesthesia or LMA/GA

Locations (1)

Hospital for Special Surgery

New York, New York, United States

Outcomes

Primary Outcomes

Readiness for Discharge

Defined as duration from arrival in the post-anesthesia care unit (PACU0 to the time patient meets the discharge criteria from the post anesthesia discharge scoring system (PADSS) for home readiness after ambulatory surgery

Time frame: Determine within 24 hours after surgery

Data from ClinicalTrials.gov

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