Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects

Amir Abbasnezhad114 enrolled

Overview

In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls. Furthermore, investigators evaluated the possible correlation of these adipokines with IBS-QoL, IBSSS, GI symptoms and other clinical and psychological disorders.

Study Type

OBSERVATIONAL

Enrollment

114

Conditions

Irritable Bowel Syndrome

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women between the ages of 18, and 80 years. * IBS patients diagnosed according to the Rome III Diagnostic Criteria for Functional GI Disorders. Exclusion Criteria: * Any evidence of abdominal surgery or radiation * celiac disease, or other primary GI illnesses * GI infection obscuring IBS symptoms, * using total parenteral nutrition therapy in the last 6 months * pregnancy and lactation * alcohol consumption * concurrent chronic diseases such as diabetes, renal failure * diagnosed and/or treated malignancy in the past 5 years * anti-inflammatory drugs usage * intake of vitamin D, omega-3, vitamin E, and calcium supplements * being on a special diet or medication regimen during the last 6 months

Locations (1)

Lorestan university of medical sciences

Khorramabad, Iran

Outcomes

Primary Outcomes

Serum levels of Apelin, Chemerin and adiponectin

Time frame: in recruitment

Secondary Outcomes

IBS-Quality of life (IBS-QoL)

The Quality of life was assessed at the baseline and at the end of the study using a self-report QoL measure specific to IBS (IBS-QoL) with 34 items

Time frame: in recruitment

IBS severity score system (IBSSS)

Irritable bowel syndrome severity score system is validated for use in IBS patients, which included five clinically relevant items during a 10-day period: (i) severity of abdominal pain, (ii) frequency of abdominal pain, (iii) severity of abdominal distention or tightness, (iv) dissatisfaction with bowel habits, and (v) interference of IBS with life in general. Each item was scored on a scale from 0 to 100, and the sum of these five items was the score of IBS severity (range 0-500). Scores of 75-175, 175-300, and \>300 indicated mild, moderate, and severe cases, respectively.

Time frame: in recruitment

Gastrointestinal symptoms

Time frame: in recruitment

Somatic Symptom

Time frame: in recruitment

Personality

Big Five Inventory Questionnaire

Time frame: in recruitment

Perceived Stress Scale

The Perceived Stress Scale (PSS) is the most widely used psychological instrument for measuring the perception of stress. It is a measure of the degree to which situations in one's life are appraised as stressful.Higher PSS scores were associated with a greater vulnerability to stressful life-event-elicited depressive symptoms. PSS scores are obtained by reversing responses (e.g., 0 = 4, 1 = 3, 2 = 2, 3 = 1 \& 4 = 0) to the four positively stated items (items 4, 5, 7, \& 8) and then summing across all scale items. A short 4 item scale can be made from questions 2, 4, 5 and 10 of the PSS 10 item scale.

Data from ClinicalTrials.gov

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