Interaction of Potassium and Genetic Risk Variants on Diabetes Risk

Duke University11,812 enrolled

Overview

The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.

Study Type

OBSERVATIONAL

Enrollment

11,812

Conditions

Diabetes

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts Exclusion Criteria: * Had not fasted 8 or more hours for the baseline visit * Prevalent diabetes at baseline exam * Missing information on serum potassium * Missing single nucleotide polymorphism (SNP) data * Evidence of kidney dysfunction * Race other than black/African American or white/Caucasian * Missing other covariates

Outcomes

Primary Outcomes

Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio

Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort

Time frame: through study completion, mean of 8 years of follow-up

Data from ClinicalTrials.gov

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