Secondary bacterial influenza pneumonia caused by Panton-Valentine Leukocidin Positive Staphylococcus aureus is a rare complication but with poor prognosis. This pathology seems to affect young patients (20-40 years) without any medical history. Since the influenza pandemic of 2009, this complication is more and more mentioned, sought and diagnosed. However, the literature is poor, consisting of case reports, experimental studies on murine models, and low-power studies. The main objective is to evaluate the mortality in intensive care units of patients post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus
Study Type
OBSERVATIONAL
Enrollment
35
Baux
Nancy, France
RECRUITINGNumber of dead patients
All cause of mortality
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Demographic data relating to age
age
Time frame: Baseline
Demographic data relating to sex
sex
Time frame: Baseline
Respiratory failure
PaO2/iFO2 value
Time frame: Baseline
Demographic data relating to immunosuppression
Amount of polynuclear neutrophils (G/L)
Time frame: Baseline
risk factors for methicillin-resistant Staphylococcus aureus
hospitalization
Time frame: Baseline
risk factors for methicillin-resistant Staphylococcus aureus
dialysis
Time frame: Baseline
risk factors for methicillin-resistant Staphylococcus aureus
surgery
Time frame: Baseline
risk factors for methicillin-resistant Staphylococcus aureus
presence of percutaneous or long-term catheter
Time frame: Baseline
Clinical data relating to pre-admission antibiotics
type of antibiotic prescribed
Time frame: Baseline
Clinical data in the initial phase relating to SAPS 2 score
Simplified acute Physiology score (SAPS2) score between 0 and 163 and a predicted mortality between 0% and 100%
Time frame: Baseline
Clinical data in the initial phase relating to SOFA admission
Sequential Organ Failure Assessment (SOFA)
Time frame: Baseline
Clinical data in the initial phase relating to neutropenia
neutropenia
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to neutropenia
thrombocytopenia
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to metabolic acidosis
metabolic acidosis
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to oxygen dependence
oxygen dependence
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to hyperthermia
hyperthermia
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to chills
chills
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to headhache
headache
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to productive cough
productive cough
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to dyspnoea
dyspnoea
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to acute respiratory failure
acute respiratory failure
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to hemoptysis
hemoptysis
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to uni - or multi - lobar infiltration on chest X - ray or CT scan
uni - or multi - lobar infiltration on chest X - ray or CT scan
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to pleural effusion
pleural effusion
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase
necrotizing pneumonitis
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Clinical data in the initial phase relating to renal failure
renal failure according to KDIGO classification
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Prognostic factors for this pathology
Time to diagnosis of influenza infection and Panton-Valentine Leukocidin Positive Staphylococcus aureus Haemoptysis, leukopenia, thrombocytopenia, acute respiratory distress syndrome (ARDS), PaO2 / Fi02, inotropic support
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Complications
Complications related to Septic shock ARDS: according to Berlin 2009 classification Extra corporeal vein-venous or veino-arterial oxygenation membrane (ECMO VV or ECMO VA) Ischemic limb Pneumothorax Acute renal failure according to Kdigo classification Disseminated intravascular coagulation (DIC) (2) Cardiogenic shock / cardiogenic pulmonary acute edema Multi visceral failure syndrome (3) Use of surgery: abscess drainage, lobectomy, amputation, laparotomy and colonic resection ...
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Collection of infectious samples
Bacteriological, Parasitological, Virological
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Probabilistic antibiotherapy
Collection of probabilistic antibiotherapy
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Probabilistic antibiotherapy
Duration of probabilistic antibiotherapy
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Prescribed antibiotic therapy
Collection of Prescribed antibiotic therapy
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Prescribed antibiotic therapy
Duration for the appropriate anti-toxin treatment
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Collection of the date of introduction of adapted antibiotic therapy
Collection of the date of introduction of adapted antibiotic therapy
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Number of patients with Influenza type A
Number of patients with Influenza type A
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Number of patients with Influenza type B
Number of patients with Influenza type B
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Date of initiation of anti-viral treatment in relation to the onset of symptoms and duration of anti-viral treatment
Date of initiation of anti-viral treatment in relation to the onset of symptoms and duration of anti-viral treatment
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Dosage of antiviral treatment
Dosage of antiviral treatment
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
Number of serious influenza infections per year and per center with early and late deaths
Mortality caused by serious inflenza infections
Time frame: During Length of stay in intensive care unit (an average of 2 weeks)
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