Transcranial Direct Current Stimulation (tDCS) in Children and Adolescents With Epilepsy and Depression

Inclusion Criteria: * Diagnosis of generalized epilepsy (confirmed by neurologist) * Diagnosis of depressive disorder (confirmed by psychiatrist), with CDRS-R score ≥ 40 * Parent/guardian ability to provide written informed consent in English, with child/adolescent participant able to provide assent (for participants \<18 years of age), or participant ability to provide written informed consent in English (for participants ≥18 years of age) * Antidepressant medications (SSRI or SNRI) permitted, provided that no dosing change has occurred in two months prior to baseline assessments; antidepressant medication not required for enrollment * AED medications (with exceptions listed below in exclusion criteria) permitted, provided that no change in AED regimen has occurred in two months prior to baseline assessments (except for weight/growth-related dosing changes); AED not required for enrollment Exclusion Criteria: * Presence of pacemaker or metallic implant (with the exception of orthodontic hardware) * Prior surgical intervention for epilepsy * More than one generalized tonic-clonic (GTC) seizure during two months prior to enrollment * AED regimen change during two months prior to baseline assessments (except dosing adjustments made strictly due to growth/weight change) * Antidepressant medication change during two months prior to baseline assessments * Lifetime history of manic/hypomanic episode or psychotic disorder * Autism spectrum disorder (ASD) diagnosis * Documented history of intellectual disability (documented full-scale IQ greater than two standard deviations below mean) * Current or recent (two months prior to baseline assessments) active substance use disorder * Imminent risk of suicide or medically serious self-injurious behavior (as evaluated by board-certified child and adolescent psychiatrist) * Current pregnancy or positive urine pregnancy test * Prohibited concomitant medications include: regularly scheduled benzodiazepines (except clobazam); barbiturates; neuroleptic/antipsychotic medications; lithium.