The primary objective of this trial is to evaluate the effect of oral administration of an Astaxanthin formulation compared to placebo after one month alone and after an additional 3 months of exercise training on mitochondrial and skeletal muscle function in elderly subjects with evidence of mitochondrial dysfunction/sarcopenia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
41
Astaxanthin formulation containing AstaReal® astaxanthin (Haematococcus pluvialis algae extract), tocotrienol, and zinc will be orally administered starting on Day 1 until Day 120
Placebo will be orally administered starting on Day 1 until Day 120.
The subjects will undergo interval treadmill incline protocol (target 85% HR max, 3 times a week for 40 to 60 minutes) starting on Day 31 until Day 120.
Fred Hutchinson Cancer Research Center Prevention Center
Seattle, Washington, United States
University of Washington Medical Center
Seattle, Washington, United States
Skeletal muscle strength and performance measured by 31P-magnetic resonance spectroscopy (31p MRS)
Skeletal muscle strength and performance will be evaluated by changes from baseline in muscle work rate calculated from the results of the leg muscle fatigue protocol testing: Baseline-Day 30-Day 120.
Time frame: Day 30 - Day 120
Muscle energetics
Muscle energetics and size measured by 31p MRS: Baseline
Time frame: Day 30-Day 120
Hand grip strength
Hand grip strength
Time frame: Day 30-Day120
6-minute walk test
6-minute walk test
Time frame: Day 30-Day 120
Safety Measures
Safety as assessed by measures such as adverse events
Time frame: Baseline-Day 30-Day 120
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