The Effects of Radium-223 Dichloride Therapy on Radionuclide Bone Scan Lesions.

functional status as indicated by score on the Eastern Cooperative Oncology Group (ECOG) performance scale

The ECOG scale describes a patient's level of functioning in terms of their ability to care for themself, daily activity, and physical ability (walking, working, etc.). The possible scores on the scale are 0 to 5, with 0 being the best outcome and 5 being the worst outcome, details of each score are listed below. Grade 0 = Fully active, able to carry on all pre-disease performance without restriction Grade 1 = Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work Grade 2 = Ambulatory and capable of all selfcare but unable to carry out any work activities; up and about more than 50% of waking hours Grade 3 = Capable of only limited selfcare; confined to bed or chair more than 50% of waking hours Grade 4 = Completely disabled; cannot carry on any selfcare; totally confined to bed or chair Grade 5 = Dead

Time frame: Pretreatment (about 1 to 3 days before each treatment) for a total of 6 treatments

pain level as assessed by numeric rating score

As assessed using numeric rating score from 1-10 with 10 being the highest level of pain

Time frame: Pretreatment (about 1 to 3 days before each treatment) for a total of 6 treatments

(PSA) prostate specific antigen level

normal level should be 4.0 ng/mL. value is measured after each dose

Time frame: pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments

(ALP) alkaline phosphatase level