Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD

Inclusion Criteria: * 40 years of age or older * Mild to moderate COPD as defined by the American Thoracic Society * Current treatment with a beta-blocker for either hypertension, myocardial infarction, or congestive heart failure. Exclusion Criteria: * Recent (within 30 days) COPD exacerbation or requirement for oral steroid therapy within the last 6 months * Any history of ventilator support requirement for COPD * Patients with asthma or reactive airway disease (RAD) defined as obstructive lung disease with a \>15% improvement in FEV1 with beta-agonist therapy * Relative or absolute contraindication to beta-blocker therapy * Exposure to any investigational drugs within the previous 30 days * Patients with any concurrent disease or condition, which in the judgment of the investigator would make the patient inappropriate for participation in the study were excluded from this study