The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy.

Rigshospitalet, Denmark21 enrolled

Overview

The study investigates the association between normalization of serum sodium levels and bone markers in patients with epilepsy and chronic hyponatremia. The study is a randomized, single blinded, placebo controlled study where participants will be randomized to either treatment with salt tablets or placebo tablets through 4 months. At the beginning and end of the 4 months bone markers will be measured. The investigators null-hypothesis is that there will be no difference in bone markers before or after the intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Hyponatremia Metabolic Bone Disease

Interventions

Sodium chlorideDRUG

Sodium chloride tablets, 250 mg

Placebo Oral TabletDRUG

Starch tablets

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Epilepsy requiring treatment for at least 2 years * Known hyponatremia (2 subsequent s-sodium values \< 136 mmol/l) * Age 18-80 years * Danish speaking * Signed form of prior consent Exclusion Criteria: * Pregnancy and breastfeeding * Known osteoporosis. DXA scan \< -2.5 T-score. Z-score is used for patients 50 years or younger. * Undergoing treatment for osteoporosis * Undergoing treatment with salt tablets * Known SIADH * Severe concomitant disease such as cancer or ischemic heart disease * Alcohol, drug or substance abuse

Locations (1)

Rigshospitalet Glostrup

Glostrup Municipality, Denmark