This is a cross-sectional cohort study which aims to compare the invasive and non-invasive assessments on aortic blood pressure and cardiac funtion in subjects without history of cardio-vascular disease. Left ventricular (LV) filling pressure, LV volume, and aortic blood pressure will be measured invasively. Non-invasive assessment includes echocardiography,aortic, and carotid blood pressure measurement.
Study Type
OBSERVATIONAL
Enrollment
100
Left ventricular (LV) polyethylene catheter was inserted into left ventricular to directly measure LV filling pressure.
Aortic blood pressure will be measured with polyethylene catheter in aortic root.
Echocardiography will be performed in all participants to assess left ventricular diastolic function non-invasively.
Left ventricular filling pressure assessment with left heart catheterization
All participants will receive invasive left ventricular filling pressure assessment with left heart catheterization.
Time frame: 1 day
Left ventricular diastolic function assessment with echocardiography using ASE recommendations
All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The ASE-recommended (American Society of Echocardiography) creteria would be used to define left ventricular diastolic dysfunction.
Time frame: 1 day
Left ventricular diastolic function assessment with echocardiography using EACVI recommendations
All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The EACVI-recommended (European Association of Cardiovascular Imaging) creteria would be used to define left ventricular diastolic dysfunction.
Time frame: 1 day
Aortic blood presure obtained with Sphygmocor device
Sphygmocor device (AtCor Medical, Australia) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.
Time frame: 1 day
Aortic blood presure obtained with PulsePen device
PulsePen device (DiaTecne SRL, Italy) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.
Time frame: 1 day
Aortic blood presure obtained with Mobil-O-Graph device
Mobil-O-Graph (IEM, Germany) device will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.
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Three devices (Sphygmocor \[AtCor Medical, Australia\], PulsePen \[DiaTecne SRL, Italy\], and Mobil-O-Graph \[IEM, Germany\] ) will be used to assess aortic blood pressure non-invasively when participants are undergoing invasive aortic blood pressure measurement.
Time frame: 1 day
Aortic blood presure obtained with catheterization
Catheterization will be used in invasive aortic blood presure measurement. The cather will be placed in the aortic root while measuring the blood pressure.
Time frame: 1 day