Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults

Inclusion Criteria: 1. Males or females between 18 and 50 years, inclusive, who are long-term residents of the study area. 2. Good general health as determined by means of the screening procedure. 3. Assumed availability for the duration of the trial (13 months). 4. Willingness to participate in the study as evidenced by signing the informed consent document. 5. Negative for hookworm during screening, or if found to be infected with hookworm, has completed a course of three doses of albendazole. Exclusion Criteria: 1. Pregnancy as determined by a positive urine human choriogonadotropin (hCG) test (if female). 2. Participant unwilling to use reliable contraception up until one month following the final immunization (if female and not surgically sterile, abstinent, at least 2 years post-menopausal, or determined otherwise by medical evaluation to be sterile). 3. Currently lactating and breast-feeding (if female). 4. Inability to correctly answer all questions on the informed consent comprehension questionnaire. 5. Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, diabetes, or renal disease by history, physical examination, and/or laboratory studies. 6. Has a diagnosis of schizophrenia, bipolar disease or other major psychiatric condition that would make compliance with study visits/procedures difficult (e.g., subject with psychoses or history of suicide attempt or gesture in the 3 years before study entry, ongoing risk for suicide). 7. Known or suspected immunodeficiency. 8. Laboratory evidence of liver disease (alanine aminotransferase \[ALT\] greater than 1.25-times the upper reference limit). 9. Laboratory evidence of renal disease (serum creatinine greater than 1.25-times the upper reference limit, or more than 1+ protein, or glucose on urine dipstick testing). 10. Laboratory evidence of hematologic disease (absolute leukocyte count \<3500/mm3; absolute leukocyte count \>11.0 x 103/mm3; hemoglobin \<10.0 g/dl \[females\] or \<12.0 g/dl \[males\]; or, platelet count \<140,000/mm3). 11. Other condition that in the opinion of the investigator could jeopardize the safety or rights of a volunteer participating in the trial or would render them unable to comply with the protocol. 12. Participation in another investigational vaccine or drug trial within 30 days of starting this study or for the duration of the study. 13. History of a severe allergic reaction or anaphylaxis. 14. Severe asthma as defined by the need for daily use of inhalers or emergency room/clinic visit or hospitalization within 6 months of the volunteer's planned first vaccination in the study. 15. Positive for HCV. 16. Positive for HBsAg. 17. Positive for HIV infection. 18. Use of corticosteroids (excluding topical or nasal) or immunosuppressive drugs within 30 days of starting this study or planned use up to one month after the volunteer's final vaccination. 19. Receipt of a live vaccine within past 4 weeks or a killed vaccine within past 2 weeks prior to entry into the study. 20. History of a surgical splenectomy. 21. Receipt of blood products within the 6 months prior to entry into the study. 22. Previous receipt of the Na-GST-1/Alhydrogel® vaccine. 23. Pre-existing autoimmune or antibody-mediated diseases including but not limited to: systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren's syndrome, autoimmune thrombocytopenia; or laboratory evidence of possible autoimmune disease determined by a positive anti-dsDNA titer, positive rheumatoid factor, proteinuria (greater than trace protein on urine dipstick testing) and/or a positive ANA.