The purpose of this study is to study on compliance, safety and effectivity of vaccination for children with hematologic malignancies or solid tumors and their parents.
Children with hematologic malignancies or solid tumors are all facing with immune deficiency due to the disease, the chemotherapy, the hematopoietic stem cell transplantation or the splenectomy, which greatly increases their chance to get infectious diseases. In this study, we will assess the compliance of children with hematologic malignancies or solid tumors and their parents to accept vaccination after finishing treatments, follow up with untoward effect questionnaires to assess the safety, obtain the serum of children patients to test antibody titers and assess the effectivity, provide clues for the study of vaccination in children with hematologic malignancies or solid tumors and provide a scientific basis for the formulation and reunification of vaccination programs.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
300
Patients with higher antibody titers will accept vaccination. There are two vaccines provided in this study: hepatitis B vaccine measles-rubella combined vaccine
Patients with higher antibody titers will NOT accept vaccination. But we will keep monitoring their antibody titers.
Shanghai Children's Medical Center
Shanghai, Shanghai Municipality, China
RECRUITINGNumber of parents of children willing to be vaccinated after receiving relevant knowledge propagation
Time frame: 2 years
Number of participants with vaccination-related adverse events
Time frame: 2 years
The level of serum antibody increased after vaccination
Time frame: 2 years
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