Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate

The Hong Kong Polytechnic University71 enrolled

Overview

Our project is a 24-month longitudinal randomized controlled trial that aims to investigate the myopia development after topical application of 0.01% atropine in children with either fast or slow myopia progression classified according to their initial electro-retinal responses. This will help elucidate the effectiveness of using low concentration atropine for myopia control in children with different myopia progression rates.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Myopia

Interventions

Atropine (0.01%)DRUG

tropical application

Artificial tearDRUG

tropical application

Eligibility

Sex: ALLMin age: 7 YearsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 7 and 10 years * Good general health and no family history of ocular diseases * No current or history of epilepsy or asthma * Myopia : -0.50 to -1.00 D (inclusive, both eyes) * Astigmatism : ≤ 0.50 D * No hyperopia, amblyopia or strabismus * No reported ocular eye diseases or disorders * No drug allergy

Locations (1)

School of Optometry, Hong Kong Polytechnic University

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

Annualized Changes in Refractive Error (SER)

Annualized changes in refractive error (SER) after receiving the 0.01 atropine or artificial tears up to 18 months

Time frame: 18 months

Secondary Outcomes

Annualized Change in Axial Length

Annualized change in axial length after receiving the 0.01 atropine or artificial tears up to 18 months

Time frame: 18 months

Data from ClinicalTrials.gov

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