A Trial of KB004 in Patients With Glioblastoma

Inclusion Criteria: * Adults (greater than or equal to 18 years of age) with histologically proven glioblastoma * Evidence of progressive glioblastoma (if within 3 months of radiotherapy, then progression outside of radiotherapy field is required) * Measurable disease by RANO (Response Assessment in Neuro-Oncology Criteria) * ECOG (Eastern Cooperative Oncology Group score) 0 to 1 * Expected survival more than 3 months * Steroid dose less than 2.5 mg per day dexamethasone equivalents and stable or reducing for 1 week prior to day 1 * Archived (formalin fixed paraffin embedded) tissue or frozen tumour tissue or consent to obtain a fresh tumour biopsy at enrolment is required. * Adequate organ function. Out of range values that are not clinically significant will be permitted, except for the following laboratory parameters which must be within the ranges specified * Neutrophils greater than or equal to 1.5 x 109 per L * Platelets greater than or equal to 100 x 109 per L * International Normalised Ratio less than or equal to 1.4 * Serum Aspartate aminotransferase and Alanine aminotransferase less than or equal to 2.5 x ULN (upper limit of normal) * Serum bilirubin less than or equal to 1.5 x ULN (upper limit of normal) Exclusion Criteria: * Evidence of infratentorial, extracranial or leptomeningeal disease * More than one prior systemic therapy for progressive disease or prior Steriotactic radiosurgery (SRS) to sites of GB (glioblastoma). * Prior treatment with bevacizumab or gliadel wafers * Evidence of current or prior intracranial hemorrhage * Need for anti-platelet or anti-coagulant drugs * Use of anti-cancer therapy including craniotomy, chemotherapy, immunotherapy, radiotherapy, or any investigational therapy within 28 days prior to Study Day 1 * History of major immunologic reaction to any immunoglobulin G containing agent * Medical conditions which place the subject at an unacceptably high risk * Subject is pregnant, lactating or unwilling or unable to use adequate contraception