Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)

Stanford University3 enrolled

Overview

The purpose of this study is to understand nitrous oxide effects in post traumatic stress disorder (PTSD)

Post traumatic stress disorder (PTSD) is a disabling mental health disorder that impacts the lives of individuals. This study aims to understand nitrous oxide's effects in PTSD.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Post Traumatic Stress Disorder

Interventions

Nitrous OxideDRUG

One hour inhalation of 50% nitrous oxide, an odorless, colorless gas FDA approved as an induction agent for dental sedation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-80 * Veterans of the United States Uniformed Services * primary diagnosis of PTSD * sufficient severity of PTSD symptoms * fluency in English * capacity to provide informed consent Exclusion Criteria: * psychiatric or medical conditions that make participation unsafe * pregnant or nursing females * allergy to nitrous oxide

Locations (1)

Veterans Affairs Palo Alto

Palo Alto, California, United States

Outcomes

Primary Outcomes

Number of Patients Who Met and Exceeded Response Criteria of Clinician Administered PTSD Scale for DSM-5 (CAPS-5)

Patients given CAPS-5 (Clinician Administered PTSD Scale for DSM-5), a 30-item structured interview that can be used to assess PTSD symptoms over the past week. For the CAPS-5 the minimum units are 0 and maximum units on the total scale are 80. The higher the number on the CAPS-5, the more severe the symptoms. Response was defined as at least a 12 point reduction on the CAPS-5

Time frame: Baseline and 1 week post inhalation

Data from ClinicalTrials.gov

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