This study aims to discover more about radiation techniques for people treated for left-sided breast cancer that minimizes exposure to the heart, as noted by mean heart dose.
This study aims to discover more about radiation techniques for people treated for left-sided breast cancer that minimizes exposure to the heart, as noted by mean heart dose. Both prone (lying face down) radiation and Deep Inspiration Breath Hold (DIBH) are more labor-intensive and usually require longer treatment times for patients than traditional supine (lying face up) free-breathing radiation treatments. Thus, identifying people that benefit most from these techniques can better utilize resources. This study compares supine and prone positioning, with or without DIBH, to further assess which positioning technique will achieve the lowest cardiac radiation doses.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
11
The DIBH technique involves the patient breathing to a specified threshold and then holding that level of inspiration during every radiation therapy field delivered.
The patient will be instructed to breathe freely.
Froedtert Hospital and Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Changes in EKG parameters prior to, during or after radiation therapy.
Changes in QRS wave form will be categorized as 'present' or 'absent' based on the presentation (or lack) of a r' wave, or notched r or s wave on the EKG tracing. QRS-T angle will be measured in degrees.
Time frame: Baseline, 6 weeks, 6 months and 12 months
Change in mitochondrial energy production, as measured in leukocytes (peripheral blood mononuclear cells) from patients prior to and after undergoing radiation therapy.
Mitochondrial energy production will be measured by determining oxygen consumption rate (pmol of O2 consumed per second per·10\^6 cells).
Time frame: baseline, 6 weeks, and 6 and 12 months post-radiation therapy
Changes in left ventricular ejection fraction prior to, during or after radiation therapy.
This will be measured as a percentage.
Time frame: Baseline and 12 months
Changes in left atrial volume prior to, during or after radiation therapy.
This will be measured in millimeters.
Time frame: Baseline and 12 months
Left ventricular wall thickness prior to, during or after radiation therapy.
This will be measured in millimeters.
Time frame: Baseline and 12 months
Arterial and aortic stiffness.
This will be assessed by measuring the ascending aortic diameters 3 cm above the aortic valve at end-diastole and end-systole in the 2D parasternal view.
Time frame: Baseline and 12 months
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